Re Genotyper: Detecting mislabeled samples in genetic data

Konrad Zych, Basten L. Snoek, Mark Elvin, Miriam Rodriguez, K. Joeri Van Der Velde, Danny Arends, Harm Jan Westra, Morris A. Swertz, Gino Poulin, Jan E. Kammenga, Rainer Breitling, Ritsert C. Jansen, Yang Li

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


In high-throughput molecular profiling studies, genotype labels can be wrongly assigned at various experimental steps; the resulting mislabeled samples seriously reduce the power to detect the genetic basis of phenotypic variation. We have developed an approach to detect potential mislabeling, recover the "ideal" genotype and identify "best-matched" labels for mislabeled samples. On average, we identified 4% of samples as mislabeled in eight published datasets, highlighting the necessity of applying a "data cleaning" step before standard data analysis.

Original languageEnglish
Article number0171324
JournalPLoS One
Issue number2
Publication statusPublished - Feb 2017
Externally publishedYes


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