Reallocating time from sedentary behavior to physical activity in patients with peripheral artery disease: Analyzing the effects on walking capacity using compositional data analysis

Antonio Henrique Germano-Soares, Rafael M. Tassitano, Breno Quintela Farah, Aluísio Andrade-Lima, Marília De Almeida Correia, Aleš Gába, Nikola Štefelová, Pedro Puech-Leao, Nelson Wolosker, Gabriel Grizzo Cucato, Raphael Mendes Ritti-Dias*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To examine the associations between physical activity (PA) and sedentary behavior (SB) with walking capacity and the effects of reallocating time from SB to PA in patients with symptomatic peripheral artery disease (PAD) using compositional data analysis. 

Methods: This cross-sectional study included 178 patients (34% females, mean age = 66 [9] y, body mass index = 27.8 [5.0] kg/m2, and ankle-brachial index = 0.60 [0.18]). Walking capacity was assessed as the total walking distance (TWD) achieved in a 6-minute walk test, while SB, light-intensity PA, and moderate to vigorous-intensity PA (MVPA) were measured by a triaxial accelerometer and conceptualized as a time-use composition. Associations between time reallocation among wake-time behaviors and TWD were determined using compositional isotemporal substitution models. 

Results: A positive association of MVPA with TWD (relative to remaining behaviors) was found in men (βilr = 66.9, SE = 21.4, P = .003) and women (βilr = 56.5, SE = 19.8; P = .005). Reallocating 30 minutes per week from SB to MVPA was associated with higher TWD in men (6.7 m; 95% confidence interval, 2.6–10.9 m) and women (4.5 m; 95% confidence interval, 1.5–7.5 m). 

Conclusions: The findings highlight, using a compositional approach, the beneficial and independent association of MVPA with walking capacity in patients with symptomatic PAD, whereas SB and light-intensity PA were not associated.

Original languageEnglish
Pages (from-to)426-432
Number of pages7
JournalJournal of Physical Activity and Health
Volume18
Issue number4
Early online date5 Mar 2021
DOIs
Publication statusPublished - 1 Apr 2021

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