Projects per year
Abstract
In this contribution, the reduction-responsive star copolymers with long-chain hyperbranched poly(ε-caprolactone) (PCL) (HyperMacs) core and disulfide bonds were synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The HyperMacs core was constructed from disulfide-containing AB2-type PCL macromonomers, which possesses length-adjustable chain segments between branching points, large cavities, low degree of crystallinity, and reduction-responsivity. After grafted with poly(ethylene glycol), the reduction-responsive star copolymers can self-assemble into micelles in aqueous solution. The obtained micelles exhibited much lower critical micelle concentration (CMC) than their linear analogues. The reduction-responsivity from disulfide bonds makes them a promising carrier candidate for trigger release of anticancer drugs. The in vitro release results confirmed that their doxorubicin (DOX)-loaded micelles exhibited desirable reduction-triggered release performance. The cellular proliferation inhibition against HepG2 cells demonstrated that the DOX-loaded micelles showed a comparable anticancer activity with free DOX. Therefore, it can be expected that the reduction-sensitive micelles may serve as smart vehicles for intracellular delivery of anti-cancer drugs in tumour therapy.
Original language | English |
---|---|
Pages (from-to) | 364-372 |
Journal | European Polymer Journal |
Volume | 108 |
Early online date | 12 Sept 2018 |
DOIs | |
Publication status | Published - 1 Nov 2018 |
Fingerprint
Dive into the research topics of 'Reduction-Responsive Amphiphilic Star Copolymers with Long-chain Hyperbranched Poly(ε-caprolactone) Core and Disulfide Bonds for Trigger Release of Anticancer Drugs'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Stimuli-responsive gel based microfluidic switch
Xu, B. B. (PI)
Engineering and Physical Sciences Research Council
1/10/15 → 30/07/17
Project: Research