TY - JOUR
T1 - Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors
AU - Freedman, Melanie S.
AU - Lucas, Robert J.
AU - Soni, Bobby
AU - von Schantz, Malcolm
AU - Muñoz, Marta
AU - David-Gray, Zoë
AU - Foster, Russell G.
PY - 1999/4/16
Y1 - 1999/4/16
N2 - Circadian rhythms of mammals are entrained by light to follow the daily solar cycle (photoentrainment). To determine whether retinal rods and cones are required for this response, the effects of light on the regulation of circadian wheel-running behavior were examined in mice lacking these photoreceptors. Mice without cones (cl) or without both rods and cones (rdta/cl) showed unattenuated phase-shifting responses to light. Removal of the eyes abolishes this behavior. Thus, neither rods nor cones are required for photoentrainment, and the murine eye contains additional photoreceptors that regulate the circadian clock.
AB - Circadian rhythms of mammals are entrained by light to follow the daily solar cycle (photoentrainment). To determine whether retinal rods and cones are required for this response, the effects of light on the regulation of circadian wheel-running behavior were examined in mice lacking these photoreceptors. Mice without cones (cl) or without both rods and cones (rdta/cl) showed unattenuated phase-shifting responses to light. Removal of the eyes abolishes this behavior. Thus, neither rods nor cones are required for photoentrainment, and the murine eye contains additional photoreceptors that regulate the circadian clock.
UR - http://www.scopus.com/inward/record.url?scp=0033574775&partnerID=8YFLogxK
U2 - 10.1126/science.284.5413.502
DO - 10.1126/science.284.5413.502
M3 - Article
C2 - 10205061
AN - SCOPUS:0033574775
SN - 0036-8075
VL - 284
SP - 502
EP - 504
JO - Science
JF - Science
IS - 5413
ER -