Relevance of systems pharmacology in drug discovery.

Lourdes Cucurull-Sanchez, Karen Spink, Sterghios Moschos

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The pharmaceutical industry is in the process of re-inventing its pipeline in an attempt to overcome its increasing phase II and III attrition rates. Here, we describe how systems pharmacology can be used as a risk assessment tool to alleviate this problem before bringing in larger investments. We propose that this translational research tool could provide a valuable, complementary addition to other emerging innovative approaches for target identification and validation in discovery and, ultimately, for aiding clinical trial optimization.
Original languageEnglish
Pages (from-to)665-670
JournalDrug Discovery Today
Volume17
Issue number13-14
DOIs
Publication statusPublished - Jul 2012

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