TY - JOUR
T1 - Relevance of systems pharmacology in drug discovery.
AU - Cucurull-Sanchez, Lourdes
AU - Spink, Karen
AU - Moschos, Sterghios
PY - 2012/7
Y1 - 2012/7
N2 - The pharmaceutical industry is in the process of re-inventing its pipeline in an attempt to overcome its increasing phase II and III attrition rates. Here, we describe how systems pharmacology can be used as a risk assessment tool to alleviate this problem before bringing in larger investments. We propose that this translational research tool could provide a valuable, complementary addition to other emerging innovative approaches for target identification and validation in discovery and, ultimately, for aiding clinical trial optimization.
AB - The pharmaceutical industry is in the process of re-inventing its pipeline in an attempt to overcome its increasing phase II and III attrition rates. Here, we describe how systems pharmacology can be used as a risk assessment tool to alleviate this problem before bringing in larger investments. We propose that this translational research tool could provide a valuable, complementary addition to other emerging innovative approaches for target identification and validation in discovery and, ultimately, for aiding clinical trial optimization.
U2 - 10.1016/j.drudis.2012.01.015
DO - 10.1016/j.drudis.2012.01.015
M3 - Article
SN - 1359-6446
VL - 17
SP - 665
EP - 670
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 13-14
ER -
