Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents

Andrea Magri, Roisin Reilly, Nicolò Scalacci, Marco Radi, Michael Hunter, Manon Ripoll, Arvind H. Patel, Daniele Castagnolo

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The discovery of a novel class of HCV inhibitors is described. The new amidinourea compounds were designed as isosteric analogues of the antiviral drug moroxydine. The two derivatives 11g and 11h showed excellent HCV inhibition activity and viability and proved to inhibit a step(s) of the RNA replication. The new compounds have been synthesized in only three synthetic steps from cheap building blocks and in high yields, thus turning to be promising drug candidates in the development of cheaper HCV treatments.
Original languageEnglish
Pages (from-to)5372-5376
JournalBioorganic & Medicinal Chemistry Letters
Volume25
Issue number22
DOIs
Publication statusPublished - 12 Sep 2015

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