Selenium in human health and disease

Susan J. Fairweather-Tait, Yongping Bao, Martin R. Broadley, Rachel Collings, Dianne Ford, John E. Hesketh, Rachel Hurst

Research output: Contribution to journalReview articlepeer-review

733 Citations (Scopus)

Abstract

This review covers current knowledge of selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system. Selenium toxicity and links between deficiency and Keshan disease and Kashin-Beck disease are described. The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility, are reviewed, and recent developments in genetics of selenoproteins are outlined. The rationale behind current dietary reference intakes of selenium is explained, and examples of differences between countries and/or expert bodies are given. Throughout the review, gaps in knowledge and research requirements are identified. More research is needed to improve our understanding of selenium metabolism and requirements for optimal health. Functions of the majority of the selenoproteins await characterization, the mechanism of absorption has yet to be identified, measures of status need to be developed, and effects of genotype on metabolism require further investigation. The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies.

Original languageEnglish
Pages (from-to)1337-1383
Number of pages47
JournalAntioxidants and Redox Signaling
Volume14
Issue number7
Early online date8 Mar 2011
DOIs
Publication statusPublished - 1 Apr 2011
Externally publishedYes

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