TY - JOUR
T1 - Self-initiated changes in physical activity and incidence of Metabolic Syndrome
T2 - A longitudinal follow-up study
AU - Werneck, André O.
AU - Christofaro, Diego Giulliano Destro
AU - Ritti-Dias, Raphael Mendes
AU - Cucato, Gabriel G.
AU - Conceição, Raquel Dilguerian de Oliveira
AU - Santos, Raul D.
AU - Bittencourt, Márcio Sommer
N1 - Funding information: We gratefully thank all the staff involved in the collection of data as well as the São Paulo Research Foundation (FAPESP) for the master's degree scholarship to AOW (FAPESP process: 2017/27234-2). RDS is a recipient of a scholarship from the Conselho Nacional de Pesquisa e Desenvolvimento Tecnologico (CNPQ) process # 303734/2018-3. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors received no funding from an external source.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Aim: The aim of this study was to analyze the association between longitudinal physical activity patterns (persistently inactive, became active, became inactive, and persistently active) and the incidence of Metabolic Syndrome (MS) among adults. Methods: Our cohort included 5766 adults (18-59y) undergoing repeated routine health screening examinations, with a mean follow-up period of three years. Only subjects without MS at baseline were included in the study. MS was defined according to the ATP III definition, including assessments of fasting blood samples for the collection of HDL-C, triglycerides and glucose, blood pressure, and waist circumference. Physical activity was estimated using the international physical activity questionnaire and four patterns were created (persistently active, became active, became inactive, and persistently inactive). Information on tobacco smoking and alcohol consumption (through structured validated questionnaires), age, interval between baseline and follow-up, anti-hypertensive drugs, statin, anti-diabetic drugs were used as covariates. Logistic regression was conducted. Results: The mean age of participants at baseline was 41.6 ± 7.9 years. We identified 1701 subjects who were active at both moments, 1246 who became active, 709 who became inactive, and 2210 who were inactive at both moments. Persistently inactive subjects presented a higher incidence of MS [10.4% (95%CI = 9.2–11.8%)]. In the adjusted logistic regression analyses, subjects that became active [OR = 0.55(95%CI = 0.40–0.74)] and persistently active [OR = 0.35(95%CI = 0.26–0.46)] were less likely to develop MS when compared with persistently inactive subjects. Conclusion: Persistently active subjects demonstrated the lowest likelihood of developing MS, while subjects who became active presented an attenuated risk.
AB - Aim: The aim of this study was to analyze the association between longitudinal physical activity patterns (persistently inactive, became active, became inactive, and persistently active) and the incidence of Metabolic Syndrome (MS) among adults. Methods: Our cohort included 5766 adults (18-59y) undergoing repeated routine health screening examinations, with a mean follow-up period of three years. Only subjects without MS at baseline were included in the study. MS was defined according to the ATP III definition, including assessments of fasting blood samples for the collection of HDL-C, triglycerides and glucose, blood pressure, and waist circumference. Physical activity was estimated using the international physical activity questionnaire and four patterns were created (persistently active, became active, became inactive, and persistently inactive). Information on tobacco smoking and alcohol consumption (through structured validated questionnaires), age, interval between baseline and follow-up, anti-hypertensive drugs, statin, anti-diabetic drugs were used as covariates. Logistic regression was conducted. Results: The mean age of participants at baseline was 41.6 ± 7.9 years. We identified 1701 subjects who were active at both moments, 1246 who became active, 709 who became inactive, and 2210 who were inactive at both moments. Persistently inactive subjects presented a higher incidence of MS [10.4% (95%CI = 9.2–11.8%)]. In the adjusted logistic regression analyses, subjects that became active [OR = 0.55(95%CI = 0.40–0.74)] and persistently active [OR = 0.35(95%CI = 0.26–0.46)] were less likely to develop MS when compared with persistently inactive subjects. Conclusion: Persistently active subjects demonstrated the lowest likelihood of developing MS, while subjects who became active presented an attenuated risk.
KW - Cardiovascular diseases
KW - Exercise
KW - MS
KW - Sedentary lifestyle
UR - http://www.scopus.com/inward/record.url?scp=85086565510&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2020.108224
DO - 10.1016/j.diabres.2020.108224
M3 - Article
C2 - 32473299
AN - SCOPUS:85086565510
SN - 0168-8227
VL - 165
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 108224
ER -