Sex Differences in Neuromuscular Aging: The Role of Sex Hormones

Jessica Piasecki, Jakob Škarabot, Padraig Spillane, Mathew Piasecki, Paul Ansdell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Males and females experience different trajectories of neuromuscular function across the lifespan, with females demonstrating accelerated deconditioning in later life. We hypothesize that the menopause is a critical period in the female lifespan, during which the dramatic reduction in sex hormone concentrations negatively impacts synaptic input to the motoneuron pool, as well as motor unit discharge properties.

Original languageEnglish
Pages (from-to)54-62
Number of pages9
JournalExercise and Sport Sciences Reviews
Issue number2
Early online date8 Feb 2024
Publication statusPublished - 1 Apr 2024

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