Sex Differences in Neuromuscular Aging: The Role of Sex Hormones

Jessica Piasecki; Jakob Škarabot; Padraig Spillane; Mathew Piasecki; Paul Ansdell

doi:10.1249/JES.0000000000000335

Sex Differences in Neuromuscular Aging: The Role of Sex Hormones

Jessica Piasecki, Jakob Škarabot, Padraig Spillane, Mathew Piasecki, Paul Ansdell^*

^*Corresponding author for this work

Sport Exercise and Rehabilitation Department

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Males and females experience different trajectories of neuromuscular function across the lifespan, with females demonstrating accelerated deconditioning in later life. We hypothesize that the menopause is a critical period in the female lifespan, during which the dramatic reduction in sex hormone concentrations negatively impacts synaptic input to the motoneuron pool, as well as motor unit discharge properties.

Original language	English
Pages (from-to)	54-62
Number of pages	9
Journal	Exercise and Sport Sciences Reviews
Volume	52
Issue number	2
Early online date	8 Feb 2024
DOIs	https://doi.org/10.1249/JES.0000000000000335
Publication status	Published - 1 Apr 2024

Keywords

Aging
Female
Gonadal Steroid Hormones
Humans
Longevity
Male
Motor Neurons/physiology
Sex Characteristics
gender
frailty
electromyography
motoneuron
endocrine

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title = "Sex Differences in Neuromuscular Aging: The Role of Sex Hormones",

abstract = "Males and females experience different trajectories of neuromuscular function across the lifespan, with females demonstrating accelerated deconditioning in later life. We hypothesize that the menopause is a critical period in the female lifespan, during which the dramatic reduction in sex hormone concentrations negatively impacts synaptic input to the motoneuron pool, as well as motor unit discharge properties.",

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AU - Spillane, Padraig

AU - Piasecki, Mathew

AU - Ansdell, Paul

N1 - Funding information: The authors declare no conflicts of interest, financial or otherwise. The authors have received grant income from multiple sources for this line of research (Office for Veteran’s Affairs, MyAge Network, Society for Endocrinology, and Royal Society).

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AB - Males and females experience different trajectories of neuromuscular function across the lifespan, with females demonstrating accelerated deconditioning in later life. We hypothesize that the menopause is a critical period in the female lifespan, during which the dramatic reduction in sex hormone concentrations negatively impacts synaptic input to the motoneuron pool, as well as motor unit discharge properties.

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KW - Longevity

KW - Male

KW - Motor Neurons/physiology

KW - Sex Characteristics

KW - gender

KW - frailty

KW - electromyography

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KW - endocrine

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JF - Exercise and Sport Sciences Reviews

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Sex Differences in Neuromuscular Aging: The Role of Sex Hormones

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Keywords

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