Skeletal-related events among breast and prostate cancer patients: Towards new treatment initiation in malaysia's hospital setting

Sharifa Wan Puteh Ezat, Syed Mohamed Aljunid Syed Junid, Noraziani Khamis*, Zafar Ahmed, Saperi Sulong, Amrizal Muhammad Nur, Azimatun Noor Aizuddin, Fuad Ismail, Norlia Abdullah, Zulkifli Md Zainuddin, Abdul Yazid Mohd Kassim, Nor Hazla Mohamed Haflah

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The human skeleton is the most common organ to be affected by metastatic cancer and bone metastases are a major cause of cancer morbidity. The five most frequent cancers in Malaysia among males includes prostate whereas breast cancer is among those in females, both being associated with skeletal lesions. Bone metastases weaken bone structure, causing a range of symptoms and complications thus developing skeletal-related events (SRE). Patients with SRE may require palliative radiotherapy or surgery to bone for pain, having hypercalcaemia, pathologic fractures, and spinal cord compression. These complications contribute to a decline in patient healthrelated quality of life. The multidimensional assessment of health-related quality of life for those patients is important other than considering a beneficial treatment impact on patient survival, since the side effects of treatment and disease symptoms can significantly impact health-related quality of life. Cancer treatment could contribute to significant financial implications for the healthcare system. Therefore, it is essential to assess the health-related quality of life and treatment cost, among prostate and breast cancer patients in countries like Malaysia to rationalized cost-effective way for budget allocation or utilization of health care resources, hence helping in providing more personalized treatment for cancer patients.

Original languageEnglish
Pages (from-to)3357-3362
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Issue number5
Publication statusPublished - 2013
Externally publishedYes


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