Solvent‑aided phase separation in hydrogel towards significantly enhanced mechanoresponsive strength

Haibao Lu*, Ziyu Xing, Mingji Chen, Kai Yu, Richard Fu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
22 Downloads (Pure)


Understanding working principles and thermodynamics behind phase separations, which have significant influences on condensed molecular structures and their performances, can inspire to design and fabricate anomalously and desirably mechanoresponsive hydrogels. However, a combination of techniques from physicochemistry and mechanics has yet been established for the phase separation in hydrogels. In this study, a thermodynamic model is firstly formulated to describe solvent-aided phase and microphase separations in the hydrogels, which present significantly improved mechanoresponsive strengths. Flory–Huggins theory and interfacial energy equation have further been applied to model the thermodynamics of concentration-dependent and temperature-dependent phase separations. An intricately detailed phase map has finally been formulated to explore the working principle. The thermodynamic methodology of phase separations, combined with the constitutive stress–strain relationships, has a great potential to explore the working mechanisms in mechanoresponsive hydrogels.
Original languageEnglish
Pages (from-to)757-766
Number of pages10
JournalActa Mechanica Sinica/Lixue Xuebao
Issue number5
Early online date16 Mar 2021
Publication statusPublished - 1 May 2021


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