TY - JOUR
T1 - Speech Illusions in People at Clinical High Risk for Psychosis Linked to Clinical Outcome
AU - EU-GEI High Risk Study
AU - Hird, Emily J
AU - Ohmuro, Noriyuki
AU - Allen, Paul
AU - Moseley, Peter
AU - Kempton, Matthew J
AU - Modinos, Gemma
AU - Sachs, Gabriele
AU - van der Gaag, Mark
AU - de Haan, Lieuwe
AU - Gadelha, Ary
AU - Bressan, Rodrigo
AU - Barrantes-Vidal, Neus
AU - Ruhrmann, Stephan
AU - Catalan, Ana
AU - McGuire, Philip
N1 - Funding information:
The European Network of National Schizophrenia Networks Studying Gene Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2- 2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme. Additional support was provided by a Medical Research Council Fellowship to M Kempton (grant MR/J008915/1), and by the Ministerio de Ciencia, Innovación e Universidades to N Barrantes-Vidal (project PSI2017-87512-C2-1-R).
PY - 2023/3/15
Y1 - 2023/3/15
N2 - BACKGROUND AND HYPOTHESIS: Around 20% of people at clinical high risk (CHR) for psychosis later develop a psychotic disorder, but it is difficult to predict who this will be. We assessed the incidence of hearing speech (termed speech illusions [SIs]) in noise in CHR participants and examined whether this was associated with adverse clinical outcomes.STUDY DESIGN: At baseline, 344 CHR participants and 67 healthy controls were presented with a computerized white noise task and asked whether they heard speech, and whether speech was neutral, affective, or whether they were uncertain about its valence. After 2 years, we assessed whether participants transitioned to psychosis, or remitted from the CHR state, and their functioning.STUDY RESULTS: CHR participants had a lower sensitivity to the task. Logistic regression revealed that a bias towards hearing targets in stimuli was associated with remission status (OR = 0.21, P = 042). Conversely, hearing SIs with uncertain valence at baseline was associated with reduced likelihood of remission (OR = 7.72. P = .007). When we assessed only participants who did not take antipsychotic medication at baseline, the association between hearing SIs with uncertain valence at baseline and remission likelihood remained (OR = 7.61, P = .043) and this variable was additionally associated with a greater likelihood of transition to psychosis (OR = 5.34, P = .029).CONCLUSIONS: In CHR individuals, a tendency to hear speech in noise, and uncertainty about the affective valence of this speech, is associated with adverse outcomes. This task could be used in a battery of cognitive markers to stratify CHR participants according to subsequent outcomes.
AB - BACKGROUND AND HYPOTHESIS: Around 20% of people at clinical high risk (CHR) for psychosis later develop a psychotic disorder, but it is difficult to predict who this will be. We assessed the incidence of hearing speech (termed speech illusions [SIs]) in noise in CHR participants and examined whether this was associated with adverse clinical outcomes.STUDY DESIGN: At baseline, 344 CHR participants and 67 healthy controls were presented with a computerized white noise task and asked whether they heard speech, and whether speech was neutral, affective, or whether they were uncertain about its valence. After 2 years, we assessed whether participants transitioned to psychosis, or remitted from the CHR state, and their functioning.STUDY RESULTS: CHR participants had a lower sensitivity to the task. Logistic regression revealed that a bias towards hearing targets in stimuli was associated with remission status (OR = 0.21, P = 042). Conversely, hearing SIs with uncertain valence at baseline was associated with reduced likelihood of remission (OR = 7.72. P = .007). When we assessed only participants who did not take antipsychotic medication at baseline, the association between hearing SIs with uncertain valence at baseline and remission likelihood remained (OR = 7.61, P = .043) and this variable was additionally associated with a greater likelihood of transition to psychosis (OR = 5.34, P = .029).CONCLUSIONS: In CHR individuals, a tendency to hear speech in noise, and uncertainty about the affective valence of this speech, is associated with adverse outcomes. This task could be used in a battery of cognitive markers to stratify CHR participants according to subsequent outcomes.
KW - signal-detection
KW - white noise task
KW - uncertainty
KW - remission
KW - transition
U2 - 10.1093/schbul/sbac163
DO - 10.1093/schbul/sbac163
M3 - Article
C2 - 36516396
SN - 0586-7614
VL - 49
SP - 339
EP - 349
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 2
M1 - sbac163
ER -