TY - JOUR
T1 - Strain-specific impacts of probiotics are a significant driver of gut microbiome development in very preterm infants
AU - Beck, Lauren C.
AU - Masi, Andrea C.
AU - Young, Greg
AU - Vatanen, Tommi
AU - Lamb, Christopher A.
AU - Smith, Rachel
AU - Coxhead, Jonathan
AU - Butler, Alana
AU - Marsland, Benjamin J.
AU - Embleton, Nicholas D.
AU - Berrington, Janet E.
AU - Stewart, Christopher J.
N1 - Funding information: We thank the NICU staff involved in the sample collection, particularly J. Groombridge. We thank the families for their willingness to help and support research. We also thank D. Smith, K. Hoffman, M. Wong and J. Petrosino (Baylor College of Medicine) for support with bioinformatic processing of raw data. This work was supported by the Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and The Royal Society (grant no. 221745/Z/20/Z), a Newcastle University Academic career Track Fellowship and the 2021 Lister Institute Prize Fellow Award. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any author-accepted manuscript version arising from this submission. Astarte Medical provided funding for stool sample retrieval and shipment for metagenomic sequencing. Tiny Lives supported set-up of the initial study and the biobanking fees. The funders played no part in the study design, analysis, interpretation or reporting.
Funding Information:
We thank the NICU staff involved in the sample collection, particularly J. Groombridge. We thank the families for their willingness to help and support research. We also thank D. Smith, K. Hoffman, M. Wong and J. Petrosino (Baylor College of Medicine) for support with bioinformatic processing of raw data. This work was supported by the Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and The Royal Society (grant no. 221745/Z/20/Z), a Newcastle University Academic career Track Fellowship and the 2021 Lister Institute Prize Fellow Award. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any author-accepted manuscript version arising from this submission. Astarte Medical provided funding for stool sample retrieval and shipment for metagenomic sequencing. Tiny Lives supported set-up of the initial study and the biobanking fees. The funders played no part in the study design, analysis, interpretation or reporting.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - The development of the gut microbiome from birth plays important roles in short- and long-term health, but factors influencing preterm gut microbiome development are poorly understood. In the present study, we use metagenomic sequencing to analyse 1,431 longitudinal stool samples from 123 very preterm infants (
AB - The development of the gut microbiome from birth plays important roles in short- and long-term health, but factors influencing preterm gut microbiome development are poorly understood. In the present study, we use metagenomic sequencing to analyse 1,431 longitudinal stool samples from 123 very preterm infants (
UR - https://www.scopus.com/pages/publications/85138811314
U2 - 10.1038/s41564-022-01213-w
DO - 10.1038/s41564-022-01213-w
M3 - Article
C2 - 36163498
SN - 2058-5276
VL - 7
SP - 1525
EP - 1535
JO - Nature Microbiology
JF - Nature Microbiology
IS - 10
ER -