Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs

Philip Burke, Lai Chun Wong, Terence Jenkins, Richard Knox, Ian Meikle, Stephen Stanforth

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
8 Downloads (Pure)

Abstract

A series of N-nitroarylated-3-chloromethyl-1,2,3,4-tetrahydroisoquinoline derivatives, several of which also possessed a trifluoromethyl substituent, were prepared and assessed as potential nitroaromatic prodrugs. The enzymatic reduction of these compounds and their cytotoxicities were studied. The compounds were cytotoxic, but this is probably not related to their enzymatic reduction.
Original languageEnglish
Pages (from-to)5851-5854
JournalBioorganic & Medicinal Chemistry Letters
Volume26
Issue number24
Early online date11 Nov 2016
DOIs
Publication statusPublished - 15 Dec 2016

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