Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating

Sankhyabrata Bandyopadhyay; Liyang Shao; Chao Wang; Shuaiqi Liu; Qiang Wu; Guoqiang Gu; Jie Hu; Yanjun Liu; Xiaolong Chen; Zhangqi Song; Xuefeng Song; Qiaoliang Bao; Mateusz Smietana

doi:10.1016/j.sbsr.2019.100320

Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating

Sankhyabrata Bandyopadhyay, Liyang Shao^*, Chao Wang, Shuaiqi Liu, Qiang Wu, Guoqiang Gu, Jie Hu, Yanjun Liu, Xiaolong Chen, Zhangqi Song, Xuefeng Song, Qiaoliang Bao, Mateusz Smietana

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Bio-chemical sensors are expected to offer high sensitivity and specificity towards the detection of an analyte. It has been found that optical sensors based on long period fiber gratings (LPFGs) meet most of these requirements, particularly when coated with thin and high-refractive index overlays with proper bio-functionalization. In this paper, the influence of properties of the overlay material on the sensitivity of LPFG sensors to bio-analytes is analyzed. It has been observed that the sensitivity of a particular cladding mode of LPFG can be changed drastically with the adhesion of few tens of ‘nm’ of bio-layers to the surface of LPFG. “Volume refractive index sensitivity” and “add-layer sensitivity” of a particular cladding mode, dynamic range, and limit of detection of the sensors have been investigated in the context of overlay materials, bio-functionalization steps, and surrounding buffer medium. The selection criteria of the thin-film deposition technique are discussed with the aim of designing highly sensitive sensors for biological and chemical applications. Concept of optimum overlay thickness has been redefined and an effective case-specific design methodology is proposed.

Original language	English
Article number	100320
Number of pages	11
Journal	Sensing and Bio-Sensing Research
Volume	27
Early online date	28 Dec 2019
DOIs	https://doi.org/10.1016/j.sbsr.2019.100320
Publication status	Published - 1 Feb 2020

Keywords

Biological and chemical sensors
Coupled mode theory
Long period fiber grating
Mode transition
Multi-layer model
Nano-layer coating

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10.1016/j.sbsr.2019.100320Licence: CC BY-NC-ND

1-s2.0-S221418041930128X-mainFinal published version, 2.04 MBLicence: CC BY-NC-ND

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title = "Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating",

abstract = "Bio-chemical sensors are expected to offer high sensitivity and specificity towards the detection of an analyte. It has been found that optical sensors based on long period fiber gratings (LPFGs) meet most of these requirements, particularly when coated with thin and high-refractive index overlays with proper bio-functionalization. In this paper, the influence of properties of the overlay material on the sensitivity of LPFG sensors to bio-analytes is analyzed. It has been observed that the sensitivity of a particular cladding mode of LPFG can be changed drastically with the adhesion of few tens of {\textquoteleft}nm{\textquoteright} of bio-layers to the surface of LPFG. “Volume refractive index sensitivity” and “add-layer sensitivity” of a particular cladding mode, dynamic range, and limit of detection of the sensors have been investigated in the context of overlay materials, bio-functionalization steps, and surrounding buffer medium. The selection criteria of the thin-film deposition technique are discussed with the aim of designing highly sensitive sensors for biological and chemical applications. Concept of optimum overlay thickness has been redefined and an effective case-specific design methodology is proposed.",

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author = "Sankhyabrata Bandyopadhyay and Liyang Shao and Chao Wang and Shuaiqi Liu and Qiang Wu and Guoqiang Gu and Jie Hu and Yanjun Liu and Xiaolong Chen and Zhangqi Song and Xuefeng Song and Qiaoliang Bao and Mateusz Smietana",

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T1 - Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating

AU - Bandyopadhyay, Sankhyabrata

AU - Shao, Liyang

AU - Wang, Chao

AU - Liu, Shuaiqi

AU - Wu, Qiang

AU - Gu, Guoqiang

AU - Hu, Jie

AU - Liu, Yanjun

AU - Chen, Xiaolong

AU - Song, Zhangqi

AU - Song, Xuefeng

AU - Bao, Qiaoliang

AU - Smietana, Mateusz

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Bio-chemical sensors are expected to offer high sensitivity and specificity towards the detection of an analyte. It has been found that optical sensors based on long period fiber gratings (LPFGs) meet most of these requirements, particularly when coated with thin and high-refractive index overlays with proper bio-functionalization. In this paper, the influence of properties of the overlay material on the sensitivity of LPFG sensors to bio-analytes is analyzed. It has been observed that the sensitivity of a particular cladding mode of LPFG can be changed drastically with the adhesion of few tens of ‘nm’ of bio-layers to the surface of LPFG. “Volume refractive index sensitivity” and “add-layer sensitivity” of a particular cladding mode, dynamic range, and limit of detection of the sensors have been investigated in the context of overlay materials, bio-functionalization steps, and surrounding buffer medium. The selection criteria of the thin-film deposition technique are discussed with the aim of designing highly sensitive sensors for biological and chemical applications. Concept of optimum overlay thickness has been redefined and an effective case-specific design methodology is proposed.

AB - Bio-chemical sensors are expected to offer high sensitivity and specificity towards the detection of an analyte. It has been found that optical sensors based on long period fiber gratings (LPFGs) meet most of these requirements, particularly when coated with thin and high-refractive index overlays with proper bio-functionalization. In this paper, the influence of properties of the overlay material on the sensitivity of LPFG sensors to bio-analytes is analyzed. It has been observed that the sensitivity of a particular cladding mode of LPFG can be changed drastically with the adhesion of few tens of ‘nm’ of bio-layers to the surface of LPFG. “Volume refractive index sensitivity” and “add-layer sensitivity” of a particular cladding mode, dynamic range, and limit of detection of the sensors have been investigated in the context of overlay materials, bio-functionalization steps, and surrounding buffer medium. The selection criteria of the thin-film deposition technique are discussed with the aim of designing highly sensitive sensors for biological and chemical applications. Concept of optimum overlay thickness has been redefined and an effective case-specific design methodology is proposed.

KW - Biological and chemical sensors

KW - Coupled mode theory

KW - Long period fiber grating

KW - Mode transition

KW - Multi-layer model

KW - Nano-layer coating

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DO - 10.1016/j.sbsr.2019.100320

M3 - Article

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ER -

Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating

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