Surface free energy and microarray deposition technology

Glen McHale

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)
10 Downloads (Pure)


Microarray techniques use a combinatorial approach to assess complex biochemical interactions. The fundamental goal is simultaneous, large-scale experimentation analogous to the automation achieved in the semiconductor industry. However, microarray deposition inherently involves liquids contacting solid substrates. Liquid droplet shapes are determined by surface and interfacial tension forces, and flows during drying. This article looks at how surface free energy and wetting considerations may influence the accuracy and reliability of spotted microarray experiments.
Original languageEnglish
Pages (from-to)192-195
Issue number3
Publication statusPublished - 2007


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