Although metabolic and cardiovascular effects of resistance exercise in type 1 diabetes (T1DM) remain poorly explored, research employing type 2 diabetes suggests glycaemic and cardiovascular benefits. However, this intense exercise carries some risks. Here we describe the cardiovascular and metabolic responses of a newly diagnosed, previously sedentary T1DM individual experiencing syncope during an unaccustomed acute bout of resistance exercise. The cause of this exercise-induced incident was attributed to inappropriate cardiovascular control and lack of habituation to accompanying acid-base disturbances. Careful consideration of exercise intensity and progression in previously sedentary T1DM performing resistance exercise sessions is warranted.