Synthesis and evaluation of novel chromogenic peptidase substrates based on 9-(4′-aminophenyl)-10-methylacridinium salts as diagnostic tools in clinical bacteriology

Rosaleen Anderson, Paul Groundwater, Yongxue Huang, Arthur James, Sylvain Orenga, Annette Rigby, Céline Roger-Dalbert, John Perry

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The synthesis and initial evaluation of novel chromogenic substrates with potential in the detection and differentiation of cultured bacterial colonies are described. The substrates were readily hydrolysed by specific aminopeptidase activity to release the chromogen, 9-(4′-aminophenyl)-10-methylacridinium salt, which provided a clear visual indication of the presence of the corresponding bacteria.
Original languageEnglish
Pages (from-to)832-835
JournalBioorganic & Medicinal Chemistry Letters
Volume18
Issue number2
DOIs
Publication statusPublished - 2008

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