Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase

Andrey Zaytsev, Rosaleen Anderson, Alexandre Bedernjak, Paul Groundwater, Yongxue Huang, John Perry, Sylvain Orenga, Céline Roger-Dalbert, Arthur James

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Novel 7-N-(β-alanyl)aminophenoxazin-3-one salts 27a-d have been synthesized and tested as chromogenic substrates for β-alanyl aminopeptidase, which is present in Pseudomonas aeruginosa, the most common respiratory pathogen in patients with cystic fibrosis. The biological results show that 7-N-(β-alanyl)amino-1-pentylphenoxazin-3-one trifluoroacetate salt 27a is a chromogenic substrate for this bacterium, with a low degree of diffusion in nutrient media for growing bacterial cultures and a bright red colour, making it easily distinguishable from the agar background.
Original languageEnglish
Pages (from-to)682-692
JournalOrganic & Biomolecular Chemistry
Volume6
Issue number4
DOIs
Publication statusPublished - 4 Jan 2008

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