Synthesis of β-Amino alcohols via the reduction of lactamides derived from Ethyl (2S)-Lactate with Borane-Methyl Sulfide

Frank Lewis; Matthias C. Eichler; David Grayson

doi:10.1055/s-0029-1217538

Synthesis of β-Amino alcohols via the reduction of lactamides derived from Ethyl (2S)-Lactate with Borane-Methyl Sulfide

Frank Lewis, Matthias C. Eichler, David Grayson

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Reactions of ethyl (2S)-lactate with various amines affords lactamides that are reduced with borane-methyl sulfide in the presence of boron trifluoride etherate to generate enantiomerically pure β-amino alcohols in good yield.

Original language	English
Pages (from-to)	1923-1928
Journal	Synlett
Volume	12
DOIs	https://doi.org/10.1055/s-0029-1217538
Publication status	Published - 2009

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title = "Synthesis of β-Amino alcohols via the reduction of lactamides derived from Ethyl (2S)-Lactate with Borane-Methyl Sulfide",

abstract = "Reactions of ethyl (2S)-lactate with various amines affords lactamides that are reduced with borane-methyl sulfide in the presence of boron trifluoride etherate to generate enantiomerically pure β-amino alcohols in good yield.",

author = "Frank Lewis and Eichler, {Matthias C.} and David Grayson",

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doi = "10.1055/s-0029-1217538",

language = "English",

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AU - Eichler, Matthias C.

AU - Grayson, David

PY - 2009

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N2 - Reactions of ethyl (2S)-lactate with various amines affords lactamides that are reduced with borane-methyl sulfide in the presence of boron trifluoride etherate to generate enantiomerically pure β-amino alcohols in good yield.

AB - Reactions of ethyl (2S)-lactate with various amines affords lactamides that are reduced with borane-methyl sulfide in the presence of boron trifluoride etherate to generate enantiomerically pure β-amino alcohols in good yield.

U2 - 10.1055/s-0029-1217538

DO - 10.1055/s-0029-1217538

M3 - Article

SN - 0936-5214

VL - 12

SP - 1923

EP - 1928

JO - Synlett

JF - Synlett

ER -

Synthesis of β-Amino alcohols via the reduction of lactamides derived from Ethyl (2S)-Lactate with Borane-Methyl Sulfide

Abstract

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