Synthesis of β-Amino alcohols via the reduction of lactamides derived from Ethyl (2S)-Lactate with Borane-Methyl Sulfide

Frank Lewis, Matthias C. Eichler, David Grayson

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Reactions of ethyl (2S)-lactate with various amines affords lactamides that are reduced with borane-methyl sulfide in the presence of boron trifluoride etherate to generate enantiomerically pure β-amino alcohols in good yield.
Original languageEnglish
Pages (from-to)1923-1928
JournalSynlett
Volume12
DOIs
Publication statusPublished - 2009

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