Vanadium complex of naturally occurring flavonoid, quercetin, is structurally characterized and evaluated for its insulin-enhancing potential, which indicates it to be a potent oral insulin-enhancing agent of therapeutic value having hypoglycemic and mitogenic activity in both type 1 and type 2 diabetes. An oxovanadium complex of quercetin (2), exhibits highly potent insulin-enhancing activity in streptozotocin-induced diabetic mice. It also mimics mitogenic potential of insulin as evaluated by [H 3]thymidine uptake assay making an effective, orally active insulin-enhancing agent for the treatment of both type 1 and type 2 diabetes without any noticeable toxic effects.
|Number of pages||5|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|Publication status||Published - 4 Oct 2004|