Abstract
Vanadium complex of naturally occurring flavonoid, quercetin, is structurally characterized and evaluated for its insulin-enhancing potential, which indicates it to be a potent oral insulin-enhancing agent of therapeutic value having hypoglycemic and mitogenic activity in both type 1 and type 2 diabetes. An oxovanadium complex of quercetin (2), exhibits highly potent insulin-enhancing activity in streptozotocin-induced diabetic mice. It also mimics mitogenic potential of insulin as evaluated by [H 3]thymidine uptake assay making an effective, orally active insulin-enhancing agent for the treatment of both type 1 and type 2 diabetes without any noticeable toxic effects.
| Original language | English |
|---|---|
| Pages (from-to) | 4961-4965 |
| Number of pages | 5 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 14 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 4 Oct 2004 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Diabetes
- Insulin mimic
- Quercetin
- Vanadium complex
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