Synthesis, structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(IV) conjugate

Ruchi Shukla; Vivek Barve; Subhash Padhye; Ramesh Bhonde

doi:10.1016/j.bmcl.2004.07.020

Synthesis, structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(IV) conjugate

Ruchi Shukla, Vivek Barve, Subhash Padhye, Ramesh Bhonde

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Vanadium complex of naturally occurring flavonoid, quercetin, is structurally characterized and evaluated for its insulin-enhancing potential, which indicates it to be a potent oral insulin-enhancing agent of therapeutic value having hypoglycemic and mitogenic activity in both type 1 and type 2 diabetes. An oxovanadium complex of quercetin (2), exhibits highly potent insulin-enhancing activity in streptozotocin-induced diabetic mice. It also mimics mitogenic potential of insulin as evaluated by [H ³]thymidine uptake assay making an effective, orally active insulin-enhancing agent for the treatment of both type 1 and type 2 diabetes without any noticeable toxic effects.

Original language	English
Pages (from-to)	4961-4965
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2004.07.020
Publication status	Published - 4 Oct 2004
Externally published	Yes

Keywords

Diabetes
Insulin mimic
Quercetin
Vanadium complex

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2004.07.020

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abstract = "Vanadium complex of naturally occurring flavonoid, quercetin, is structurally characterized and evaluated for its insulin-enhancing potential, which indicates it to be a potent oral insulin-enhancing agent of therapeutic value having hypoglycemic and mitogenic activity in both type 1 and type 2 diabetes. An oxovanadium complex of quercetin (2), exhibits highly potent insulin-enhancing activity in streptozotocin-induced diabetic mice. It also mimics mitogenic potential of insulin as evaluated by [H 3]thymidine uptake assay making an effective, orally active insulin-enhancing agent for the treatment of both type 1 and type 2 diabetes without any noticeable toxic effects.",

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AU - Barve, Vivek

AU - Padhye, Subhash

AU - Bhonde, Ramesh

PY - 2004/10/4

Y1 - 2004/10/4

N2 - Vanadium complex of naturally occurring flavonoid, quercetin, is structurally characterized and evaluated for its insulin-enhancing potential, which indicates it to be a potent oral insulin-enhancing agent of therapeutic value having hypoglycemic and mitogenic activity in both type 1 and type 2 diabetes. An oxovanadium complex of quercetin (2), exhibits highly potent insulin-enhancing activity in streptozotocin-induced diabetic mice. It also mimics mitogenic potential of insulin as evaluated by [H 3]thymidine uptake assay making an effective, orally active insulin-enhancing agent for the treatment of both type 1 and type 2 diabetes without any noticeable toxic effects.

AB - Vanadium complex of naturally occurring flavonoid, quercetin, is structurally characterized and evaluated for its insulin-enhancing potential, which indicates it to be a potent oral insulin-enhancing agent of therapeutic value having hypoglycemic and mitogenic activity in both type 1 and type 2 diabetes. An oxovanadium complex of quercetin (2), exhibits highly potent insulin-enhancing activity in streptozotocin-induced diabetic mice. It also mimics mitogenic potential of insulin as evaluated by [H 3]thymidine uptake assay making an effective, orally active insulin-enhancing agent for the treatment of both type 1 and type 2 diabetes without any noticeable toxic effects.

KW - Diabetes

KW - Insulin mimic

KW - Quercetin

KW - Vanadium complex

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DO - 10.1016/j.bmcl.2004.07.020

M3 - Article

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SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis, structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(IV) conjugate

Abstract

Keywords

UN SDGs

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