Synthetic Procedures, Properties, and Applications of Thiophene-Based Azo Scaffolds

Man Vir Singh*, Ajay Kumar Tiwari, Yogendra Kumar Sharma, Manendra S. Chauhan, Muneesh Sethi, Zhanhu Guo

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)
3 Downloads (Pure)


The thiophene nucleus has been established as the potential entity in heterocyclic chemistry's growing chemical world with promising pharmacological activities. Thiophene-based azo dyes compounds synthesized through different routes bear variable magnitudes of various activities such as textile, food, cosmetic, polymer, leather articles, paints, and ink industries numerous potential applications accredited to the azo function. The double bond linkage between two N atoms is widely found as a chief scaffold in a massive library of organic compounds with promising industrial and biological properties. The knowledge of various synthetic pathways and the diverse physicochemical parameters of such compounds draw the special attention of medicinal chemists to produce a combinatorial library. The present review provides a broad view of the synthesis and properties of compounds with thiophene nuclei. Therefore, it is a significant surge in designing novel azo dyes and introducing advanced synthetic routes for their preparation.

Original languageEnglish
Article number887
JournalES Food and Agroforestry
Publication statusPublished - 10 May 2023

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