Systematic review and meta-analysis of prevalence of undiagnosed major cardiac comorbidities in COPD

Joseph Kibbler*, Clare Wade, Grace Mussell, David P. Ripley, Stephen C. Bourke, John Steer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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BackgroundIt is often stated that heart disease is underdiagnosed in COPD. Evidence for this statement comes from primary studies, but these have not been synthesised to provide a robust estimate of the burden of undiagnosed heart disease.MethodsA systematic review of studies using active diagnostic techniques to establish the prevalence of undiagnosed major cardiac comorbidities in patients with COPD was carried out. MEDLINE, Embase, Scopus and Web of Science were searched for terms relating to heart failure (specifically, left ventricular systolic dysfunction (LVSD), coronary artery disease (CAD) and atrial fibrillation), relevant diagnostic techniques and COPD. Studies published since 1980, reporting diagnosis rates using recognised diagnostic criteria in representative COPD populations not known to have heart disease were included. Studies were classified by condition diagnosed, diagnostic threshold used and whether participants had stable or exacerbated COPD. Random-effects meta-analysis of prevalence was conducted where appropriate.ResultsIn general, prevalence estimates for undiagnosed cardiac comorbidities in COPD had broad confidence intervals, with significant study heterogeneity. Most notably, a prevalence of undiagnosed LVSD of 15.8% (11.1-21.1%) was obtained when defined as left ventricular ejection fraction ConclusionFurther studies using recent diagnostic advances, and investigating therapeutic interventions for patients with COPD and heart disease are needed.
Original languageEnglish
Pages (from-to)00548-2023
Number of pages9
JournalERJ Open Research
Issue number6
Early online date19 Oct 2023
Publication statusPublished - 1 Nov 2023

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