Tailored supramolecular gel and microemulsion crystallization strategies – is isoniazid really monomorphic?

Stuart R. Kennedy; Christopher D. Jones; Dmitry S. Yufit; Catherine E. Nicholson; Sharon J. Cooper; Jonathan W. Steed

doi:10.1039/C8CE00066B

Tailored supramolecular gel and microemulsion crystallization strategies – is isoniazid really monomorphic?

Stuart R. Kennedy, Christopher D. Jones, Dmitry S. Yufit, Catherine E. Nicholson, Sharon J. Cooper, Jonathan W. Steed

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We report the application of supramolecular gel and microemulsion droplet crystallisation methodologies to isoniazid crystallization. Tailored gelators have been designed with isoniazid mimetic functionality in an attempt to control crystal morphology and polymorphic behaviour. Microemulsion crystallisation was investigated to achieve thermodynamic control over drug crystallisation. Both techniques resulted in only a single form of isoniazid implying that it is genuinely monomorphic.

Original language	English
Pages (from-to)	1390-1398
Journal	CrystEngComm
Volume	20
Issue number	10
Early online date	12 Feb 2018
DOIs	https://doi.org/10.1039/C8CE00066B
Publication status	Published - 14 Mar 2018

Access to Document

10.1039/C8CE00066B

http://dro.dur.ac.uk/24105/

Cite this

@article{66f726ff6ebc43cf85a14f4ba5baa699,

title = "Tailored supramolecular gel and microemulsion crystallization strategies – is isoniazid really monomorphic?",

abstract = "We report the application of supramolecular gel and microemulsion droplet crystallisation methodologies to isoniazid crystallization. Tailored gelators have been designed with isoniazid mimetic functionality in an attempt to control crystal morphology and polymorphic behaviour. Microemulsion crystallisation was investigated to achieve thermodynamic control over drug crystallisation. Both techniques resulted in only a single form of isoniazid implying that it is genuinely monomorphic.",

author = "Kennedy, {Stuart R.} and Jones, {Christopher D.} and Yufit, {Dmitry S.} and Nicholson, {Catherine E.} and Cooper, {Sharon J.} and Steed, {Jonathan W.}",

year = "2018",

month = mar,

day = "14",

doi = "10.1039/C8CE00066B",

language = "English",

volume = "20",

pages = "1390--1398",

journal = "CrystEngComm",

issn = "1466-8033",