Tailored supramolecular gel and microemulsion crystallization strategies – is isoniazid really monomorphic?

Stuart R. Kennedy, Christopher D. Jones, Dmitry S. Yufit, Catherine E. Nicholson, Sharon J. Cooper, Jonathan W. Steed

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    We report the application of supramolecular gel and microemulsion droplet crystallisation methodologies to isoniazid crystallization. Tailored gelators have been designed with isoniazid mimetic functionality in an attempt to control crystal morphology and polymorphic behaviour. Microemulsion crystallisation was investigated to achieve thermodynamic control over drug crystallisation. Both techniques resulted in only a single form of isoniazid implying that it is genuinely monomorphic.
    Original languageEnglish
    Pages (from-to)1390-1398
    JournalCrystEngComm
    Volume20
    Issue number10
    Early online date12 Feb 2018
    DOIs
    Publication statusPublished - 14 Mar 2018

    Fingerprint

    Dive into the research topics of 'Tailored supramolecular gel and microemulsion crystallization strategies – is isoniazid really monomorphic?'. Together they form a unique fingerprint.

    Cite this