Targeting the TLR4–MD2 axis in systemic sclerosis

Steven O’Reilly, Jacob M. van Laar

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.

Original languageEnglish
Article numbere98850
Pages (from-to)564-566
Number of pages3
JournalNature Reviews Rheumatology
Issue number10
Early online date14 Sept 2018
Publication statusPublished - 1 Oct 2018


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