Targeting the TLR4–MD2 axis in systemic sclerosis

Steven O’Reilly; Jacob M. van Laar

doi:10.1038/s41584-018-0077-6

Targeting the TLR4–MD2 axis in systemic sclerosis

Steven O’Reilly, Jacob M. van Laar

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.

Original language	English
Article number	e98850
Pages (from-to)	564-566
Number of pages	3
Journal	Nature Reviews Rheumatology
Volume	14
Issue number	10
Early online date	14 Sept 2018
DOIs	https://doi.org/10.1038/s41584-018-0077-6
Publication status	Published - 1 Oct 2018

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10.1038/s41584-018-0077-6

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abstract = "Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.",

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AB - Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.

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Targeting the TLR4–MD2 axis in systemic sclerosis

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