tDCS application for postural control in Parkinson's disease: Effects are associated with baseline characteristics

Victor Spiandor Beretta, Diego Orcioli-Silva, Núbia Ribeiro Conceição, Priscila Nóbrega-Sousa, Marcelo Pinto Pereira, Lilian Teresa Bucken Gobbi, Rodrigo Vitório*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction Transcranial direct current stimulation (tDCS) improves postural response to perturbation in patients with Parkinson's disease (PwPD). However, the influence of baseline characteristics such as clinical/cognitive and postural performance on the response to tDCS remains unclear. Objective To investigate whether baseline level of postural control (performance during sham condition) and clinical/cognitive characteristics are associated with tDCS-related changes in postural responses to external perturbations in PwPD. Methods Twenty-four PwPD participated in this study. Clinical assessment included disease severity, disease duration, levodopa equivalent dose and global cognition. Anodal tDCS protocols targeting the primary motor cortex were applied in two separate sessions (at least 2 weeks apart): active (2 mA for 20 min) and sham stimulation. Seven trials with the backward translation of the support base (20 cm/s and 5 cm) were performed after tDCS. Postural outcomes included the recovery time to stable position and onset latency of the medial gastrocnemius (MG). Pearson and Spearman correlation tests were performed. Results No significant correlations were observed between clinical/cognitive characteristics and tDCS-related changes in postural responses. Negative associations were observed between the baseline level of postural control and tDCS-related changes in postural responses for the recovery time (r = −0.657; p 
Original languageEnglish
JournalParkinsonism & Related Disorders
Early online date13 Nov 2021
DOIs
Publication statusE-pub ahead of print - 13 Nov 2021

Fingerprint

Dive into the research topics of 'tDCS application for postural control in Parkinson's disease: Effects are associated with baseline characteristics'. Together they form a unique fingerprint.

Cite this