Over the past 40 years, the Bayh-Dole Act has been the most inspired piece of legislation around the world. This policy measure has empowered organizations to be the owners of inventions made by federally-funded research, as well as this policy has ensured royalties, licensing, and spinning-off to the organizations that have made these inventions. In the Latin-American context, technology transfer policies to support entrepreneurial innovations have been characterized by the strengthening of university-industry partnerships. This chapter discussed the evolution of determinants and outcomes of technology transfer policies implemented in Brazil. Our findings provide useful implications for academics and policymakers.