The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study

COG-UK HOCI Variant Substudy Consortium, The COVID-19 Genomics UK (COG-UK) Consortium, Florencia A. T. Boshier, Cristina Venturini, Oliver Stirrup, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela H. Becket, Matthew Byott, Themoula Charalampous, Ana da Silva Filipe, Dan Frampton, Sharon Glaysher, Tabassum Khan, Raghavendran Kulasegara-Shylini, Beatrix Kele, Irene M. Monahan, Guy Mollett, Matthew Parker, Emanuela PelosiPaul Randell, Sunando Roy, Joshua F. Taylor, Sophie J. Weller, Eleri Wilson-Davies, Phillip Wade, Rachel Williams, Andrew J. Copas, Teresa Cutino-Moguel, Nick Freemantle, Andrew C. Hayward, Alison Holmes, Joseph Hughes, Tabitha W. Mahungu, Gaia Nebbia, Eleni Nastouli, David G. Partridge, Cassie F. Pope, James R. Price, Samuel C. Robson, Kordo Saeed, Gee Yen Shin, Thushan I. de Silva, Luke B. Snell, Emma C. Thomson, Adam A. Witney, Judith Breuer*, Matthew Bashton, Andrew Nelson, Clare McCann, Darren Smith, Greg Young

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
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Objectives: Recently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in increased transmission within hospitals. Methods: We collected viral sequences and epidemiological data of patients with community and healthcare associated SARS-CoV-2 infections, sampled from 16th November 2020 to 10th January 2021, from nine hospitals participating in the COG-UK HOCI study. Outbreaks were identified using ward information, lineage and pairwise genetic differences between viral sequences. Results: Mixed effects logistic regression analysis of 4184 sequences showed healthcare-acquired infections were no more likely to be identified as the Alpha variant than community acquired infections. Nosocomial outbreaks were investigated based on overlapping ward stay and SARS-CoV-2 genome sequence similarity. There was no significant difference in the number of patients involved in outbreaks caused by the Alpha variant compared to outbreaks caused by other lineages. Conclusions: We find no evidence to support it causing more nosocomial transmission than previous lineages. This suggests that the stringent infection prevention measures already in place in UK hospitals contained the spread of the Alpha variant as effectively as other less transmissible lineages, providing reassurance of their efficacy against emerging variants of concern.

Original languageEnglish
Pages (from-to)693-700
Number of pages8
JournalJournal of Infection
Issue number6
Early online date2 Oct 2021
Publication statusPublished - 1 Dec 2021


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