The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays

Yifan Li; Ekaterina McKenna; William Parkes; Andrew Pitt; Anthony Walton

doi:10.1063/1.3626037

The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays

Yifan Li, Ekaterina McKenna, William Parkes, Andrew Pitt, Anthony Walton

Mechanical and Construction Engineering Department

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A protein microarray hybridisation system has been implemented by employing patterned hydrophobic thin films on hydrophilic substrates as a means of confinement for aqueous samples. This approach has the ability to handle, and keep separate, small sample volumes of just a few microlitres. In addition, the system is more straight forward to use than the existing multi-well gasket solution. The paper describes the fabrication method and the system is demonstrated for a model protein microarray assay.

Original language	English
Pages (from-to)	073703
Journal	Applied Physics Letters
Volume	99
Issue number	7
DOIs	https://doi.org/10.1063/1.3626037
Publication status	Published - 2011

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title = "The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays",

abstract = "A protein microarray hybridisation system has been implemented by employing patterned hydrophobic thin films on hydrophilic substrates as a means of confinement for aqueous samples. This approach has the ability to handle, and keep separate, small sample volumes of just a few microlitres. In addition, the system is more straight forward to use than the existing multi-well gasket solution. The paper describes the fabrication method and the system is demonstrated for a model protein microarray assay.",

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AU - Parkes, William

AU - Pitt, Andrew

AU - Walton, Anthony

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AB - A protein microarray hybridisation system has been implemented by employing patterned hydrophobic thin films on hydrophilic substrates as a means of confinement for aqueous samples. This approach has the ability to handle, and keep separate, small sample volumes of just a few microlitres. In addition, the system is more straight forward to use than the existing multi-well gasket solution. The paper describes the fabrication method and the system is demonstrated for a model protein microarray assay.

U2 - 10.1063/1.3626037

DO - 10.1063/1.3626037

M3 - Article

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VL - 99

SP - 073703

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 7

ER -

The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays

Abstract

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