TY - JOUR
T1 - The bodyweight walking distance product and its relationship with clinical markers in patients with symptomatic peripheral artery disease
AU - Santanna, Fernando da Silva
AU - Cunha, Paolo M.
AU - Costa, Renan Massena
AU - Cucato, Gabriel Grizzo
AU - Wolosker, Nelson
AU - Dal Corso, Simone
AU - Kanegusuku, Hélcio
AU - Farah, Breno Quintella
AU - Ritti-Dias, Raphael Mendes
AU - Correia, Marilia de Almeida
N1 - Funding information: GGC received a grant from The Brazilian National Council for Scientific and Technological Development (CNPq #409707/2016-3). PMC is supported by the São Paulo Research Foundation (FAPESP) with a postdoctoral fellowship (FAPESP process: 2021/01318-0). Coordination for the Improvement of Higher Education Personnel (CAPES #1).
PY - 2024/6/1
Y1 - 2024/6/1
N2 - PurposeThe six-minute walk test (6MWT) is extensively employed to evaluate gait impairment in patients with symptomatic peripheral artery disease (PAD) and has been associated with different health outcomes. However, various approaches exist for calculating and interpreting the six-minute test in order to address the needs of patients more effectively. Therefore, we investigated how these different approaches correlate with functional capacity and cardiovascular health in patients with symptomatic PAD.MethodsIn total, 227 PAD patients [65.2% men and 67 (13) y.o.] were included in this cross-sectional study. The 6MWT was performed along a 30-meter corridor and the distance was expressed in three ways: absolute (described as the meters walked during the test), relativized (based on the results of the 6MWT in healthy individuals), and DW (multiplying the body weight in kilograms by the absolute distance in the 6MWT). A functional capacity z-score was calculated using the results of the handgrip strength test, 4-meter walking test, and sit-and-stand test. A cardiovascular parameter z-score was calculated with data on brachial and central blood pressure, the low-frequency component/high-frequency component ratio, and carotid-femoral pulse wave velocity.ResultsThe absolute (b = 0.30, 95%CI: 18-0.43, R² = 0.11, p < 0.001) and DW (b = 0.40, 95%CI: 27-0.53, R² = 0.17, p < 0.001) measures were related to functional capacity, independently of sex, age, and the ankle-arm index of the patients. Neither absolute nor DW were related to cardiovascular health. The relativized measure was not associated with either functional capacity or cardiovascular health.ConclusionIn patients with symptomatic PAD, absolute and DW measures are related to functional capacity, but not cardiovascular function.
AB - PurposeThe six-minute walk test (6MWT) is extensively employed to evaluate gait impairment in patients with symptomatic peripheral artery disease (PAD) and has been associated with different health outcomes. However, various approaches exist for calculating and interpreting the six-minute test in order to address the needs of patients more effectively. Therefore, we investigated how these different approaches correlate with functional capacity and cardiovascular health in patients with symptomatic PAD.MethodsIn total, 227 PAD patients [65.2% men and 67 (13) y.o.] were included in this cross-sectional study. The 6MWT was performed along a 30-meter corridor and the distance was expressed in three ways: absolute (described as the meters walked during the test), relativized (based on the results of the 6MWT in healthy individuals), and DW (multiplying the body weight in kilograms by the absolute distance in the 6MWT). A functional capacity z-score was calculated using the results of the handgrip strength test, 4-meter walking test, and sit-and-stand test. A cardiovascular parameter z-score was calculated with data on brachial and central blood pressure, the low-frequency component/high-frequency component ratio, and carotid-femoral pulse wave velocity.ResultsThe absolute (b = 0.30, 95%CI: 18-0.43, R² = 0.11, p < 0.001) and DW (b = 0.40, 95%CI: 27-0.53, R² = 0.17, p < 0.001) measures were related to functional capacity, independently of sex, age, and the ankle-arm index of the patients. Neither absolute nor DW were related to cardiovascular health. The relativized measure was not associated with either functional capacity or cardiovascular health.ConclusionIn patients with symptomatic PAD, absolute and DW measures are related to functional capacity, but not cardiovascular function.
KW - Cardiovascular system
KW - Functional capacity
KW - Intermittent claudication
KW - Six-minute walk test
UR - http://www.scopus.com/inward/record.url?scp=85186106596&partnerID=8YFLogxK
U2 - 10.1016/j.jvn.2024.02.002
DO - 10.1016/j.jvn.2024.02.002
M3 - Article
AN - SCOPUS:85186106596
SN - 1062-0303
VL - 42
SP - 105
EP - 109
JO - Journal of Vascular Nursing
JF - Journal of Vascular Nursing
IS - 2
ER -