The creative industries are seen as a key part of economic development policy for national and regional policymakers. This research adopts a relational approach to examine the spatialities and networks of connections that workers in the North East of England's creative industries forge and maintain over space. Based on a questionnaire survey and interviews, our findings reveal a set of industries that are isolated from the major hubs of creativity outside the region and display a regionally bounded set of working and engagement practices. Numerous reasons underpinning this isolation are outlined, which are generated, in part, by both physical and relational distance to other agents in similar sectors. We also examine a group of highly mobile creative workers whose working practices and previous experience outside the North East allows them to overcome barriers faced by their counterparts. The paper concludes by calling for further comparative research to better understand the connectivity of regional creative industries that also avoids privileging London as the only source of discursive and financial influence. A series of recommendations for policy makers tasked with fostering the creative industries is outlined.