An entrepreneurial society refers to places where knowledge-based entrepreneurship has emerged as a driving force for economic growth, employment creation and competitiveness. In this context, entrepreneurial universities play an important role as both knowledge-producer and a disseminating institution. In the literature, several studies contributed with relevant findings. Most of these studies reveal a tendency to use case studies to explain this phenomenon justified by the embryonic nature of the topic field, and with the lack of a robust theoretical framework to understand it. No empirical study, however, has highlighted the interrelations among environmental and internal factors that conditioned the development of entrepreneurial universities with the teaching, research and entrepreneurial missions that they need to achieve. This paper aims to contribute to a better understanding of these interrelations identifying the most critical factors that conditioned these missions and to this end brings a proposal model to measure this phenomenon empirically in the light of the Institutional Economics and the Resource-Based View. The methodology adopted is integrated by the Spanish Entrepreneurial University Scoreboard to identify this phenomenon and Structural Equation Modeling to analyze the relationships among independent and dependent variables that integrate the proposal model of entrepreneurial university. This research could cover invaluable strategies to bring further benefits to society (in terms of the creation of new business and employment) and, in particular, to educational institutions.