The emerging role of metabolism in fibrosis

John Henderson, Steven O'Reilly*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


The metabolic shift that cancer cells undergo towards aerobic glycolysis was identified as a defining feature in tumours almost 100 years ago; however, it has only recently become apparent that similar metabolic reprogramming is a key feature in other diseases - with fibrosis now entering the fray. In this perspective, an overview of the recent evidence implicating increased glycolysis and glutaminolysis as mediators of fibrosis is presented, with a particular emphasis on the novel therapeutic possibilities this introduces. Furthermore, the impact that metabolic reprogramming has on redox homeostasis is discussed, providing an insight into how this often-overlooked mechanism may drive the pathogenesis. [Abstract copyright: Crown Copyright © 2021. Published by Elsevier Ltd. All rights reserved.]
Original languageEnglish
Pages (from-to)639-653
Number of pages15
JournalTrends in Endocrinology and Metabolism
Issue number8
Early online date20 May 2021
Publication statusPublished - 1 Aug 2021


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