Abstract
Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction in SSc is characterized by the activation and recruitment of immune cells and the production of autoantibodies and cytokines. How immune abnormalities link the fibrosis and vasculopathy in SSc is poorly understood. A plethora of immune cell types are implicated in the immunopathogenesis of SSc, including T cells, B cells, dendritic cells, mast cells and macrophages. How these different cell types interact to contribute to SSc is complicated, and can involve cell‐to‐cell interactions and communication via cytokines, including transforming growth factor (TGF)‐β, interleukin (IL)‐6 and IL‐4. We will attempt to review significant and recent research demonstrating the importance of immune cell regulation in the immunopathogenesis of SSc with a particular focus on fibrosis.
| Original language | English |
|---|---|
| Pages (from-to) | 310-321 |
| Number of pages | 12 |
| Journal | Clinical and Experimental Immunology |
| Volume | 195 |
| Issue number | 3 |
| Early online date | 10 Dec 2018 |
| DOIs | |
| Publication status | Published - 1 Mar 2019 |
Keywords
- arthritis (including rheumatoid arthritis)
- B cells
- T cells
- Toll-like receptors (TLRs)