This article seeks to assess the prospects of UK forensic science and technology in a post-Brexit world by analysing four interlocking issues: Brexit itself, the evolution of national criminal justice organisational and funding priorities, the increasing interrelationship of science and technology in the forensic domain and the relatively disadvantaged place of forensic science and technology within the contemporary ‘scientific state’ paradigm. The results are generally pessimistic for the likely future of forensic science. This conclusion is reinforced by scepticism about the wisdom of proceeding with Brexit. The article is structured to identify the potential implications of British political decisions on its national forensic science landscape. Some aspects of the analysis are likely to have a wider resonance for international discourse about the future sustainability of forensic science and technology, however, particularly the interface between the globalisation of science and technology with justice.