The impact of the SARS-CoV-2 pandemic and COVID-19 on lung transplantation in the UK: Lessons learned from the first wave

NHS Blood, Transplant Cardiothoracic Advisory Group Clinical Audit Group; Gillian Hardman; Ruth Sutcliffe; Rachel Hogg; Lisa Mumford; Laura Grocott; Sarah-Jane Mead-Regan; Jane Nuttall; Stephanie Dunn; Philip Seeley; Stephen Clark; Richard Quigley; Nawwar Al-Attar; Karen Booth; John H Dark; Andrew J Fisher

doi:10.1111/ctr.14210

The impact of the SARS-CoV-2 pandemic and COVID-19 on lung transplantation in the UK: Lessons learned from the first wave

NHS Blood, Transplant Cardiothoracic Advisory Group Clinical Audit Group, Gillian Hardman^*, Ruth Sutcliffe, Rachel Hogg, Lisa Mumford, Laura Grocott, Sarah-Jane Mead-Regan, Jane Nuttall, Stephanie Dunn, Philip Seeley, Stephen Clark, Richard Quigley, Nawwar Al-Attar, Karen Booth, John H Dark, Andrew J Fisher

^*Corresponding author for this work

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: Lung transplantation is particularly susceptible to the impact of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, and evaluation of changes to practice is required to inform future decision-making.

METHODS: A retrospective review of the UK Transplant Registry (UKTR) and national survey of UK lung transplant centers has been performed.

RESULTS: There was geographic variation in the prevalence of COVID-19 infection across the UK. The number of donors fell by 48% during the early pandemic period. Lung utilization fell to 10% (compared with 24% for the same period of 2019). The number of lung transplants performed fell by 77% from 53, March to May 2019, to 12. Seven (58%) of these were performed in a single-center, designated "COVID-light." The number of patients who died on the lung transplant waiting list increased, compared to the same period of 2019 (p = .0118). Twenty-six lung transplant recipients with confirmed COVID-19 infection were reported during the study period.

CONCLUSION: As the pandemic continues, reviewing practice and implementing the lessons learned during this period, including the use of robust donor testing strategies and the provision of "COVID-light" hospitals, are vital in ensuring the safe continuation of our lung transplant program.

Original language	English
Article number	e14210
Number of pages	10
Journal	Clinical Transplantation
Volume	35
Issue number	3
Early online date	1 Feb 2021
DOIs	https://doi.org/10.1111/ctr.14210
Publication status	Published - 1 Mar 2021

Keywords

coronavirus pandemic
COVID‐19
lung transplantation
organ donation
SARS‐CoV‐2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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ctr.14210Final published version, 798 KBLicence: CC BY-NC-ND

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NHS Blood, Transplant Cardiothoracic Advisory Group Clinical Audit Group, Hardman, G., Sutcliffe, R., Hogg, R., Mumford, L., Grocott, L., Mead-Regan, S.-J., Nuttall, J., Dunn, S., Seeley, P., Clark, S., Quigley, R., Al-Attar, N., Booth, K., Dark, J. H., & Fisher, A. J. (2021). The impact of the SARS-CoV-2 pandemic and COVID-19 on lung transplantation in the UK: Lessons learned from the first wave. Clinical Transplantation, 35(3), Article e14210. https://doi.org/10.1111/ctr.14210

@article{791d6a72e6e2425f9e8a99cfbafd55ef,

title = "The impact of the SARS-CoV-2 pandemic and COVID-19 on lung transplantation in the UK: Lessons learned from the first wave",

abstract = "BACKGROUND: Lung transplantation is particularly susceptible to the impact of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, and evaluation of changes to practice is required to inform future decision-making.METHODS: A retrospective review of the UK Transplant Registry (UKTR) and national survey of UK lung transplant centers has been performed.RESULTS: There was geographic variation in the prevalence of COVID-19 infection across the UK. The number of donors fell by 48% during the early pandemic period. Lung utilization fell to 10% (compared with 24% for the same period of 2019). The number of lung transplants performed fell by 77% from 53, March to May 2019, to 12. Seven (58%) of these were performed in a single-center, designated {"}COVID-light.{"} The number of patients who died on the lung transplant waiting list increased, compared to the same period of 2019 (p = .0118). Twenty-six lung transplant recipients with confirmed COVID-19 infection were reported during the study period.CONCLUSION: As the pandemic continues, reviewing practice and implementing the lessons learned during this period, including the use of robust donor testing strategies and the provision of {"}COVID-light{"} hospitals, are vital in ensuring the safe continuation of our lung transplant program.",

keywords = "coronavirus pandemic, COVID‐19, lung transplantation, organ donation, SARS‐CoV‐2",

author = "{NHS Blood, Transplant Cardiothoracic Advisory Group Clinical Audit Group} and Gillian Hardman and Ruth Sutcliffe and Rachel Hogg and Lisa Mumford and Laura Grocott and Sarah-Jane Mead-Regan and Jane Nuttall and Stephanie Dunn and Philip Seeley and Stephen Clark and Richard Quigley and Nawwar Al-Attar and Karen Booth and Dark, {John H} and Fisher, {Andrew J}",

note = "{\textcopyright} 2021 The Authors. Clinical Transplantation published by John Wiley & Sons Ltd.",

year = "2021",

month = mar,

day = "1",

doi = "10.1111/ctr.14210",

language = "English",

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NHS Blood, Transplant Cardiothoracic Advisory Group Clinical Audit Group, Hardman, G, Sutcliffe, R, Hogg, R, Mumford, L, Grocott, L, Mead-Regan, S-J, Nuttall, J, Dunn, S, Seeley, P, Clark, S, Quigley, R, Al-Attar, N, Booth, K, Dark, JH & Fisher, AJ 2021, 'The impact of the SARS-CoV-2 pandemic and COVID-19 on lung transplantation in the UK: Lessons learned from the first wave', Clinical Transplantation, vol. 35, no. 3, e14210. https://doi.org/10.1111/ctr.14210

The impact of the SARS-CoV-2 pandemic and COVID-19 on lung transplantation in the UK: Lessons learned from the first wave. / NHS Blood, Transplant Cardiothoracic Advisory Group Clinical Audit Group; Hardman, Gillian; Sutcliffe, Ruth et al.
In: Clinical Transplantation, Vol. 35, No. 3, e14210, 01.03.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The impact of the SARS-CoV-2 pandemic and COVID-19 on lung transplantation in the UK

T2 - Lessons learned from the first wave

AU - NHS Blood, Transplant Cardiothoracic Advisory Group Clinical Audit Group

AU - Hardman, Gillian

AU - Sutcliffe, Ruth

AU - Hogg, Rachel

AU - Mumford, Lisa

AU - Grocott, Laura

AU - Mead-Regan, Sarah-Jane

AU - Nuttall, Jane

AU - Dunn, Stephanie

AU - Seeley, Philip

AU - Clark, Stephen

AU - Quigley, Richard

AU - Al-Attar, Nawwar

AU - Booth, Karen

AU - Dark, John H

AU - Fisher, Andrew J

PY - 2021/3/1

Y1 - 2021/3/1

N2 - BACKGROUND: Lung transplantation is particularly susceptible to the impact of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, and evaluation of changes to practice is required to inform future decision-making.METHODS: A retrospective review of the UK Transplant Registry (UKTR) and national survey of UK lung transplant centers has been performed.RESULTS: There was geographic variation in the prevalence of COVID-19 infection across the UK. The number of donors fell by 48% during the early pandemic period. Lung utilization fell to 10% (compared with 24% for the same period of 2019). The number of lung transplants performed fell by 77% from 53, March to May 2019, to 12. Seven (58%) of these were performed in a single-center, designated "COVID-light." The number of patients who died on the lung transplant waiting list increased, compared to the same period of 2019 (p = .0118). Twenty-six lung transplant recipients with confirmed COVID-19 infection were reported during the study period.CONCLUSION: As the pandemic continues, reviewing practice and implementing the lessons learned during this period, including the use of robust donor testing strategies and the provision of "COVID-light" hospitals, are vital in ensuring the safe continuation of our lung transplant program.

AB - BACKGROUND: Lung transplantation is particularly susceptible to the impact of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, and evaluation of changes to practice is required to inform future decision-making.METHODS: A retrospective review of the UK Transplant Registry (UKTR) and national survey of UK lung transplant centers has been performed.RESULTS: There was geographic variation in the prevalence of COVID-19 infection across the UK. The number of donors fell by 48% during the early pandemic period. Lung utilization fell to 10% (compared with 24% for the same period of 2019). The number of lung transplants performed fell by 77% from 53, March to May 2019, to 12. Seven (58%) of these were performed in a single-center, designated "COVID-light." The number of patients who died on the lung transplant waiting list increased, compared to the same period of 2019 (p = .0118). Twenty-six lung transplant recipients with confirmed COVID-19 infection were reported during the study period.CONCLUSION: As the pandemic continues, reviewing practice and implementing the lessons learned during this period, including the use of robust donor testing strategies and the provision of "COVID-light" hospitals, are vital in ensuring the safe continuation of our lung transplant program.

KW - coronavirus pandemic

KW - COVID‐19

KW - lung transplantation

KW - organ donation

KW - SARS‐CoV‐2

U2 - 10.1111/ctr.14210

DO - 10.1111/ctr.14210

M3 - Article

C2 - 33368697

SN - 0902-0063

VL - 35

JO - Clinical Transplantation

JF - Clinical Transplantation

IS - 3

M1 - e14210

ER -

The impact of the SARS-CoV-2 pandemic and COVID-19 on lung transplantation in the UK: Lessons learned from the first wave

Abstract

Keywords

UN SDGs

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