Injury rates in running range from 19.4‐79.3%, with injuries at the knee comprising 42.1%. Pronation and altered frontal plane knee joint range of motion have been linked to such injuries. The influence of foot structure on pronation and knee kinematics has not been examined in running. This study examined associations between great toe valgus angle, peak pronation angle and frontal plane range of movement at the knee joint during overground running while barefoot. Great toe valgus angle while standing, and peak pronation angle and frontal plane range of motion of the dominant leg during stance while running barefoot on an indoor track were recorded in fifteen recreational runners. There was a large, negative association between great toe valgus angle and peak pronation angle (r = -0.52, p = 0.04), and a strong positive association between great toe valgus angle and frontal plane range of motion at the knee joint (r = 0.67, p = 0.006). The results suggest that great toe position plays an important role in foot stability and upstream knee-joint motion. The role of forefoot structure as a factor for knee-joint injury has received little attention and could be a fruitful line of enquiry in the exploration of factors underpinning running-related knee injuries.