The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study

Rachel Kimble, Lucy Murray, Karen Keane, Karen Haggerty, Glyn Howatson, John Lodge*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Montmorency tart cherries (MC) have been found to modulate indices of vascular function with interventions of varying duration. The objective of this preliminary study was to identify the chronic effects of MC supplementation on vascular function and the potential for urinary metabolomics to provide mechanistic evidence. We performed a placebo-controlled, double-blind, randomised study on 23 healthy individuals (18M, 7F) that consumed 30 ml MC or a placebo twice daily for 28 days. Whole body measures of vascular function and spot urine collections were taken at baseline and after supplementation. There were no significant changes to vascular function including blood pressure and arterial stiffness. Urinary metabolite profiling highlighted significant changes (P < 0.001) with putative discriminatory metabolites related to tryptophan and histidine metabolism. Overall, MC supplementation for 28 days does not improve indices of vascular function but changes to the urinary metabolome could be suggestive of potential mechanisms.

Original languageEnglish
Article numbere73
Pages (from-to)1-5
Number of pages5
JournalJournal of Nutritional Science
Volume10
DOIs
Publication statusPublished - 13 Sep 2021

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