The Influence of Tart Cherry (Prunus cerasus, cv Montmorency) Concentrate Supplementation for 3 Months on Cardiometabolic Risk Factors in Middle-Aged Adults: A Randomised, Placebo-Controlled Trial

Rachel Kimble; Karen Keane; John Lodge; Glyn Howatson

doi:10.3390/nu13051417

The Influence of Tart Cherry (Prunus cerasus, cv Montmorency) Concentrate Supplementation for 3 Months on Cardiometabolic Risk Factors in Middle-Aged Adults: A Randomised, Placebo-Controlled Trial

Rachel Kimble, Karen Keane, John Lodge, Glyn Howatson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Tart Montmorency cherries (MC) have been shown to be rich in anthocyanins and other phytochemicals known to have anti-inflammatory properties and influence pathways that might improve cardiometabolic health. However, there is limited evidence for the longer-term use of tart cherries on these indices. The aim of the current study was to investigate the influence of MC concentrate on cardiometabolic health indices following a 3-month supplementation period.Methods: Fifty middle-aged adults (34 males and 16 females; mean ± SD age: 48 ± 6 years and BMI: 27.6 ± 3.7 kg/m2) completed a randomised, placebo-controlled parallel study in which they either received MC or an isocaloric placebo. Participants drank 30 ml of their allocated treatment twice per day for 3 months. Vascular function (blood pressure [BP], heart rate [HR], pulse wave velocity and analysis [PWV/A] and flow mediated dilation [FMD]) as well as indices of meta-bolic health (insulin, glucose, lipid profiles and high sensitivity C reactive protein) were measured following an overnight fast before and after the 3 months.Results: No effect of the intervention between groups was observed for vascular function or metabolic health variables following the intervention (P> 0.05). However, MC concentrate was shown to be safe and well tolerated and importantly did not have any deleterious effects on these outcomes. In conclusion MC has no in-fluence on cardiometabolic indices in middle-aged adults.

Original language	English
Article number	1417
Number of pages	17
Journal	Nutrients
Volume	13
Issue number	5
DOIs	https://doi.org/10.3390/nu13051417
Publication status	Published - 23 Apr 2021

Keywords

tart cherry
cardiovascular disease
vascular function
metabolic health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/nu13051417Licence: CC BY

Accepted versionAccepted author manuscript, 430 KBLicence: CC BY
nutrients-13-01417Final published version, 883 KBLicence: CC BY

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@article{af2e00eb215c468c803ab0006d59721d,

title = "The Influence of Tart Cherry (Prunus cerasus, cv Montmorency) Concentrate Supplementation for 3 Months on Cardiometabolic Risk Factors in Middle-Aged Adults: A Randomised, Placebo-Controlled Trial",

abstract = "Background: Tart Montmorency cherries (MC) have been shown to be rich in anthocyanins and other phytochemicals known to have anti-inflammatory properties and influence pathways that might improve cardiometabolic health. However, there is limited evidence for the longer-term use of tart cherries on these indices. The aim of the current study was to investigate the influence of MC concentrate on cardiometabolic health indices following a 3-month supplementation period.Methods: Fifty middle-aged adults (34 males and 16 females; mean ± SD age: 48 ± 6 years and BMI: 27.6 ± 3.7 kg/m2) completed a randomised, placebo-controlled parallel study in which they either received MC or an isocaloric placebo. Participants drank 30 ml of their allocated treatment twice per day for 3 months. Vascular function (blood pressure [BP], heart rate [HR], pulse wave velocity and analysis [PWV/A] and flow mediated dilation [FMD]) as well as indices of meta-bolic health (insulin, glucose, lipid profiles and high sensitivity C reactive protein) were measured following an overnight fast before and after the 3 months.Results: No effect of the intervention between groups was observed for vascular function or metabolic health variables following the intervention (P> 0.05). However, MC concentrate was shown to be safe and well tolerated and importantly did not have any deleterious effects on these outcomes. In conclusion MC has no in-fluence on cardiometabolic indices in middle-aged adults.",

keywords = "tart cherry, cardiovascular disease, vascular function, metabolic health",

author = "Rachel Kimble and Karen Keane and John Lodge and Glyn Howatson",

note = "Funding information: This study was supported by Northumbria University and the Cherry Research Committee, a not-for-profit organisation, for a Collaborative Doctoral Research Studentship Scheme. The external funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

year = "2021",

month = apr,

day = "23",

doi = "10.3390/nu13051417",

language = "English",

volume = "13",

journal = "Nutrients",

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AU - Kimble, Rachel

AU - Keane, Karen

AU - Lodge, John

AU - Howatson, Glyn

N1 - Funding information: This study was supported by Northumbria University and the Cherry Research Committee, a not-for-profit organisation, for a Collaborative Doctoral Research Studentship Scheme. The external funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PY - 2021/4/23

Y1 - 2021/4/23

N2 - Background: Tart Montmorency cherries (MC) have been shown to be rich in anthocyanins and other phytochemicals known to have anti-inflammatory properties and influence pathways that might improve cardiometabolic health. However, there is limited evidence for the longer-term use of tart cherries on these indices. The aim of the current study was to investigate the influence of MC concentrate on cardiometabolic health indices following a 3-month supplementation period.Methods: Fifty middle-aged adults (34 males and 16 females; mean ± SD age: 48 ± 6 years and BMI: 27.6 ± 3.7 kg/m2) completed a randomised, placebo-controlled parallel study in which they either received MC or an isocaloric placebo. Participants drank 30 ml of their allocated treatment twice per day for 3 months. Vascular function (blood pressure [BP], heart rate [HR], pulse wave velocity and analysis [PWV/A] and flow mediated dilation [FMD]) as well as indices of meta-bolic health (insulin, glucose, lipid profiles and high sensitivity C reactive protein) were measured following an overnight fast before and after the 3 months.Results: No effect of the intervention between groups was observed for vascular function or metabolic health variables following the intervention (P> 0.05). However, MC concentrate was shown to be safe and well tolerated and importantly did not have any deleterious effects on these outcomes. In conclusion MC has no in-fluence on cardiometabolic indices in middle-aged adults.

AB - Background: Tart Montmorency cherries (MC) have been shown to be rich in anthocyanins and other phytochemicals known to have anti-inflammatory properties and influence pathways that might improve cardiometabolic health. However, there is limited evidence for the longer-term use of tart cherries on these indices. The aim of the current study was to investigate the influence of MC concentrate on cardiometabolic health indices following a 3-month supplementation period.Methods: Fifty middle-aged adults (34 males and 16 females; mean ± SD age: 48 ± 6 years and BMI: 27.6 ± 3.7 kg/m2) completed a randomised, placebo-controlled parallel study in which they either received MC or an isocaloric placebo. Participants drank 30 ml of their allocated treatment twice per day for 3 months. Vascular function (blood pressure [BP], heart rate [HR], pulse wave velocity and analysis [PWV/A] and flow mediated dilation [FMD]) as well as indices of meta-bolic health (insulin, glucose, lipid profiles and high sensitivity C reactive protein) were measured following an overnight fast before and after the 3 months.Results: No effect of the intervention between groups was observed for vascular function or metabolic health variables following the intervention (P> 0.05). However, MC concentrate was shown to be safe and well tolerated and importantly did not have any deleterious effects on these outcomes. In conclusion MC has no in-fluence on cardiometabolic indices in middle-aged adults.

KW - tart cherry

KW - cardiovascular disease

KW - vascular function

KW - metabolic health

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DO - 10.3390/nu13051417

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The Influence of Tart Cherry (Prunus cerasus, cv Montmorency) Concentrate Supplementation for 3 Months on Cardiometabolic Risk Factors in Middle-Aged Adults: A Randomised, Placebo-Controlled Trial

Abstract

Keywords

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