The Ketogenic Diet in the Treatment of Schizophrenia

Zoltán Sarnyai, Ann-Katrin Kraeuter, Christopher M. Palmer

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Evidence is emerging that supports the use of ketogenic dietary intervention in the treatment of schizophrenia and other chronic psychotic disorders. The cause of schizophrenia is unknown. Current theories include the dopamine hypothesis and the view that schizophrenia is a neurodevelopmental disorder. Emerging evidence suggests that bioenergetics and mitochondrial dysfunction may play a role. Long-standing clinical and epidemiologic observations have found high prevalence rates of obesity, diabetes, cardiovascular disease, and premature mortality in people with schizophrenia, suggesting a connection with metabolic disorders. The ketogenic diet is a metabolic intervention that may improve bioenergetic deficiencies in the brains of people with schizophrenia, resulting in improvement of clinical symptoms. Basic science, animal, and human studies are reviewed and synthesized in order to explore this exciting and emerging field.
Original languageEnglish
Title of host publicationKetogenic Diet and Metabolic Therapies
Subtitle of host publicationExpanded Roles in Health and Disease
EditorsSusan A. Masino
Place of PublicationOxford
PublisherOxford University Press
Number of pages16
ISBN (Electronic)9780197501238
ISBN (Print)9780197501207
Publication statusPublished - 1 Apr 2022


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