The recent advances in the mathematical modelling of human pluripotent stem cells

Laura E. Wadkin; Sirio Orozco-Fuentes; Irina Neganova; Majlinda Lako; Anvar Shukurov; Nicholas G.  Parker

doi:10.1007/s42452-020-2070-3

The recent advances in the mathematical modelling of human pluripotent stem cells

Laura E. Wadkin, Sirio Orozco-Fuentes, Irina Neganova, Majlinda Lako, Anvar Shukurov, Nicholas G. Parker

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Abstract

Human pluripotent stem cells hold great promise for developments in regenerative medicine and drug design. The mathematical modelling of stem cells and their properties is necessary to understand and quantify key behaviours and develop non-invasive prognostic modelling tools to assist in the optimisation of laboratory experiments. Here, the recent advances in the mathematical modelling of hPSCs are discussed, including cell kinematics, cell proliferation and colony formation, and pluripotency and differentiation.

Original language	English
Article number	276
Number of pages	14
Journal	SN Applied Sciences
Volume	2
Issue number	2
Early online date	27 Jan 2020
DOIs	https://doi.org/10.1007/s42452-020-2070-3
Publication status	Published - Feb 2020
Externally published	Yes

Keywords

Mathematical modelling
Human pluripotent stem cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s42452-020-2070-3Licence: CC BY

Wadkin2020_Article_TheRecentAdvancesInTheMathematFinal published version, 2.23 MBLicence: CC BY

Cite this

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AU - Shukurov, Anvar

AU - Parker, Nicholas G.

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AB - Human pluripotent stem cells hold great promise for developments in regenerative medicine and drug design. The mathematical modelling of stem cells and their properties is necessary to understand and quantify key behaviours and develop non-invasive prognostic modelling tools to assist in the optimisation of laboratory experiments. Here, the recent advances in the mathematical modelling of hPSCs are discussed, including cell kinematics, cell proliferation and colony formation, and pluripotency and differentiation.

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The recent advances in the mathematical modelling of human pluripotent stem cells

Abstract

Keywords

UN SDGs

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