TY - JOUR
T1 - The role of the superior temporal lobe in auditory false perceptions
T2 - a transcranial direct current stimulation study
AU - Moseley, Peter
AU - Fernyhough, Charles
AU - Ellison, Amanda
N1 - Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Neuroimaging has shown that a network of cortical areas, which includes the superior temporal gyrus, is active during auditory verbal hallucinations (AVHs). In the present study, healthy, non-hallucinating participants (N=30) completed an auditory signal detection task, in which participants were required to detect a voice in short bursts of white noise, with the variable of interest being the rate of false auditory verbal perceptions. This paradigm was coupled with transcranial direct current stimulation, a noninvasive brain stimulation technique, to test the involvement of the left posterior superior temporal gyrus in the creation of auditory false perceptions. The results showed that increasing the levels of excitability in this region led to a higher rate of 'false alarm' responses than when levels of excitability were decreased, with false alarm responses under a sham stimulation condition lying at a mid-point between anodal and cathodal stimulation conditions. There were also corresponding changes in signal detection parameters. These results are discussed in terms of prominent cognitive neuroscientific theories of AVHs, and potential future directions for research are outlined.
AB - Neuroimaging has shown that a network of cortical areas, which includes the superior temporal gyrus, is active during auditory verbal hallucinations (AVHs). In the present study, healthy, non-hallucinating participants (N=30) completed an auditory signal detection task, in which participants were required to detect a voice in short bursts of white noise, with the variable of interest being the rate of false auditory verbal perceptions. This paradigm was coupled with transcranial direct current stimulation, a noninvasive brain stimulation technique, to test the involvement of the left posterior superior temporal gyrus in the creation of auditory false perceptions. The results showed that increasing the levels of excitability in this region led to a higher rate of 'false alarm' responses than when levels of excitability were decreased, with false alarm responses under a sham stimulation condition lying at a mid-point between anodal and cathodal stimulation conditions. There were also corresponding changes in signal detection parameters. These results are discussed in terms of prominent cognitive neuroscientific theories of AVHs, and potential future directions for research are outlined.
KW - Acoustic Stimulation
KW - Adolescent
KW - Adult
KW - Color Perception/physiology
KW - Female
KW - Functional Laterality
KW - Hallucinations/etiology
KW - Humans
KW - Male
KW - Signal Detection, Psychological
KW - Temporal Lobe/physiology
KW - Transcranial Direct Current Stimulation/adverse effects
KW - Young Adult
U2 - 10.1016/j.neuropsychologia.2014.07.032
DO - 10.1016/j.neuropsychologia.2014.07.032
M3 - Article
C2 - 25107678
VL - 62
SP - 202
EP - 208
JO - Neuropsychologia
JF - Neuropsychologia
SN - 0028-3932
ER -