The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents

Lucy Chappel, Lai Chun Wong, Chee-Onn Leong, Chun-Wai Mai, Meikle Ian, Steven Stanforth, Viet Thang Truong

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Abstract

Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities.
Original languageEnglish
Article number126910
JournalBioorganic and Medicinal Chemistry Letters
Volume30
Issue number4
Early online date19 Dec 2019
DOIs
Publication statusPublished - 15 Feb 2020

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