The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents

Lucy Chappel; Lai Chun Wong; Chee-Onn Leong; Chun-Wai Mai; Meikle Ian; Steven Stanforth; Viet Thang Truong

doi:10.1016/j.bmcl.2019.126910

The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents

Lucy Chappel, Lai Chun Wong, Chee-Onn Leong, Chun-Wai Mai, Meikle Ian, Steven Stanforth, Viet Thang Truong

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Abstract

Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities.

Original language	English
Article number	126910
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	30
Issue number	4
Early online date	19 Dec 2019
DOIs	https://doi.org/10.1016/j.bmcl.2019.126910
Publication status	Published - 15 Feb 2020

Keywords

nitroaromatic drugs
anti-cancer agents
trifluoromethylated drugs
nitrogen mustards

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2019.126910

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title = "The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents",

abstract = "Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds{\textquoteright} cytotoxicities. ",

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AU - Chappel, Lucy

AU - Chun Wong, Lai

AU - Leong, Chee-Onn

AU - Mai, Chun-Wai

AU - Ian, Meikle

AU - Stanforth, Steven

AU - Truong, Viet Thang

PY - 2020/2/15

Y1 - 2020/2/15

N2 - Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities.

AB - Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities.

KW - nitroaromatic drugs

KW - anti-cancer agents

KW - trifluoromethylated drugs

KW - nitrogen mustards

UR - https://www.scopus.com/pages/publications/85076830664

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DO - 10.1016/j.bmcl.2019.126910

M3 - Article

SN - 0960-894X

VL - 30

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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M1 - 126910

ER -

The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents

Abstract

Keywords

UN SDGs

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