The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents

Lucy Chappel; Lai Chun Wong; Chee-Onn Leong; Chun-Wai Mai; Meikle Ian; Steven Stanforth; Viet Thang Truong

doi:10.1016/j.bmcl.2019.126910

The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents

Lucy Chappel, Lai Chun Wong, Chee-Onn Leong, Chun-Wai Mai, Meikle Ian, Steven Stanforth, Viet Thang Truong

Research output: Contribution to journal › Article › peer-review

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Abstract

Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities.

Original language	English
Article number	126910
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	30
Issue number	4
Early online date	19 Dec 2019
DOIs	https://doi.org/10.1016/j.bmcl.2019.126910
Publication status	Published - 15 Feb 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

nitroaromatic drugs
anti-cancer agents
trifluoromethylated drugs
nitrogen mustards

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10.1016/j.bmcl.2019.126910

Mustard_paper_for_pure_Accepted author manuscript, 791 KBLicence: CC BY-NC-ND
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Cite this

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abstract = "Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds{\textquoteright} cytotoxicities. ",

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AU - Chappel, Lucy

AU - Chun Wong, Lai

AU - Leong, Chee-Onn

AU - Mai, Chun-Wai

AU - Ian, Meikle

AU - Stanforth, Steven

AU - Truong, Viet Thang

PY - 2020/2/15

Y1 - 2020/2/15

N2 - Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities.

AB - Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities.

KW - nitroaromatic drugs

KW - anti-cancer agents

KW - trifluoromethylated drugs

KW - nitrogen mustards

UR - https://www.scopus.com/pages/publications/85076830664

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DO - 10.1016/j.bmcl.2019.126910

M3 - Article

SN - 0960-894X

VL - 30

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents

Abstract

UN SDGs

Keywords

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