This chapter reviews the efficacy of the ketogenic diet in a variety of neurodegenerative, neurodevelopmental and metabolic conditions throughout different stages of life. It describes conditions affecting children, metabolic disorders in adults and disorderrs affecting the elderly. We have focused on application of the ketogenic diet in clinical studies and in preclinical models and discuss the benefits and negative aspects of the diet. Finally, we highlight the need for further research in this area with a view of discovering novel mechanistic targets of the ketogenic diet, as a means of maximising the potential benefits/risks ratio.
|Title of host publication||Reviews on Biomarker Studies in Aging and Anti-Aging Research|
|Editors||Paul C. Guest|
|Place of Publication||Cham|
|Number of pages||25|
|Publication status||Published - 7 Sep 2019|
|Name||Advances in Experimental Medicine and Biology|