The use of a systems approach to increase NAD+ in human participants

John D. Henderson, Sophia N. Z. Quigley, Shruti S. Chachra, Nichola Conlon*, Dianne Ford*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Reversal or mitigation against an age-related decline in NAD+ has likely benefits, and this premise has driven academic and commercial endeavour to develop dietary supplements that achieve this outcome. We used a systems-based approach to improve on current supplements by targeting multiple points in the NAD+ salvage pathway. In a double-blind, randomised, crossover trial, the supplement - Nuchido TIME+® (NT) - increased NAD+ concentration in whole blood. This was associated with an increase in SIRT1 and an increase in nicotinamide phosphoribosyltransferase (NAMPT) in peripheral blood mononucleocytes, lower concentrations of pro-inflammatory cytokines in plasma, including a reduction in interleukin 2 (IL2), a reduction in glycated serum protein and a shift in the glycosylation profile of immunoglobulin G (IgG) toward a younger biological age, all of which are likely to promote a healthier ageing trajectory.
Original languageEnglish
Article number7
Number of pages12
Journalnpj Aging and Mechanisms of Disease
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Feb 2024

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