Toward a PCR-Independent Molecular Diagnosis of Veterinary and Medically Relevant Pathogenic Organisms

Matthew Partington, Dino Masic, Audrey Nicholson, John Perry, Andrew Berrington, Jonatan West, Olivier Sparagano

Research output: Contribution to journalArticlepeer-review

Abstract

Bloodstream infections caused by bacteria and fungi are a major problem worldwide. These bloodstream infections can affect both people and livestock, placing a significant burden upon developed and developing economies. In this paper we describe a multiplexed testing format, which can identify a range of bacteria and fungi within a single blood sample. Key to this technique is the specificity and sensitivity of the nucleotide probes that capture the sample. The sensitivity and specificity of the probes may allow detection of disease-causing microorganisms without the need for polymerase chain reaction amplification if the dynamics of probe binding can be observed in real time.
Original languageEnglish
Pages (from-to)391-393
JournalAnnals of the New York Academy of Sciences
Volume1149
Issue number1
DOIs
Publication statusPublished - 2008

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